Related Experiment Video

Updated: May 16, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

[Dynamics of laboratory markers of endothelial dysfunction during treatment of unstable angina]

A P Roĭtman, B M Tankhilevich, V V Dolgov

    Klinicheskaia Meditsina
    |December 11, 2012
    PubMed

    Insights

    This study found that endothelin-1 (ET1) levels increase in patients with unstable angina (UA) and severe coronary heart disease (CHD). Elevated ET1 indicates a poor prognosis in these patients.

    Area of Science:

    • Cardiovascular Medicine
    • Biomarker Research
    • Clinical Diagnostics

    Context:

    • Unstable angina (UA) is a critical manifestation of coronary heart disease (CHD).
    • Identifying reliable diagnostic and prognostic markers for UA is essential for patient management.
    • Endothelial dysfunction plays a key role in the pathophysiology of UA.

    Purpose:

    • To evaluate the diagnostic utility of specific laboratory markers for endothelial lesions in patients diagnosed with unstable angina.
    • To assess the dynamic changes in these markers over a 4-month follow-up period.
    • To correlate laboratory findings with the clinical progression of coronary heart disease.

    Summary:

    • Plasma levels of C-reactive protein (CRP), homocysteine, endothelin-1 (ET1), and pregnancy-associated plasma protein-A (PAPP-A) were measured in 51 UA patients.
    • Elevated baseline CRP levels persisted throughout the study.
    • Significantly decreased PAPP-A and homocysteine levels were observed, while elevated ET1 levels correlated with a deteriorated clinical picture of CHD.

    Impact:

    • Endothelin-1 (ET1) emerges as a significant indicator of endothelial lesions in unstable angina.
    • Elevated ET1 levels are associated with severe and prognostically unfavorable coronary heart disease.
    • These findings may contribute to improved risk stratification and therapeutic strategies for UA patients.

    More Related Videos

    Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

    Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

    Published on: January 28, 2020

    Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test06:35

    Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

    Published on: April 27, 2016

    Related Concept Videos

    Angina V: Nursing Management01:20

    Angina V: Nursing Management

    Angina, a symptom of myocardial ischemia, requires a structured nursing management approach to ensure effective care and prevent complications like myocardial infarction. Comprehensive nursing care involves assessing, diagnosing, planning, implementing interventions, and evaluating outcomes, all tailored to the individual patient's needs.Patient AssessmentNursing assessment begins with a detailed subjective evaluation of symptoms, which typically include chest pain or pressure radiating to the...
    Angina III: Clinical Manifestations and Assessment01:29

    Angina III: Clinical Manifestations and Assessment

    Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
    Acute Coronary Syndrome III: Diagnostic Studies01:30

    Acute Coronary Syndrome III: Diagnostic Studies

    Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
    Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

    Blood Studies for Cardiovascular System I: Cardiac Biomarkers

    Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
    The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
    Troponins
    Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
    Antianginal Drugs: Nitrates and β-Blockers01:16

    Antianginal Drugs: Nitrates and β-Blockers

    In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
    Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
    Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

    Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

    Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
    These markers indicate stress or strain on the heart muscle:
    Natriuretic Peptides (BNP)
    Cardiac myocytes produce these hormones in response to ventricular stretching...