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[Possibilities for assessing unilateral functional disorders of the upper urinary tract in infants with urethral
D Berger1, R Bertrand, A Bischof-Delaloye
1Kinderchirurgische, Centre Hospitalier Universitaire Vaudois, Lausanne, Schweiz.
Insights
This study evaluated upper urinary tract function in infants with urethral valves. Diagnostic tests precisely assessed renal performance for prognosis and follow-up.
Area of Science:
- Pediatric Nephrology
- Urology
Context:
- Infants diagnosed with urethral valves require careful monitoring of renal function.
- Urethral valves can impact bladder and upper urinary tract development and function.
Purpose:
- To evaluate upper urinary tract function in infants with diagnosed urethral valves.
- To assess the diagnostic and prognostic value of various renal function tests.
Summary:
- Fifteen infants with urethral valves were studied; one infant was excluded due to early mortality.
- Renal function was assessed in 10 infants using the Hodson index, creatinine, PAH, inulin clearance, and renal I123-Hippuran scintigraphy.
- These methods provided precise evaluation of individual kidney function at diagnosis, for prognosis, and during follow-up.
Impact:
- Established the utility of specific diagnostic procedures for assessing renal function in infants with urethral valves.
- Aids in the precise prognosis and long-term management of pediatric patients with obstructive uropathy.
Abstract:
Upper urinary tract function was evaluated in 15 infants in whom urethral valves were diagnosed. One baby died at 16 days of age and was not completely investigated. In 4, the valves did not have untoward effect on the bladder and the upper urinary tract. In 10 others, function was evaluated using the Hodson index, creatinine, PAH, inuline clearance and renal I123-Hippuran scintigraphy with measurement of the accumulation indices. The various examination procedures were of value in providing precise evaluation of the renal performances at diagnosis as well as in prognosis and follow-up of the function of each kidney.