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Biomimetic synthesis of thiaplidiaquinones A and B
Iman M Khalil1, David Barker, Brent R Copp
1School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Journal of Natural Products
|December 11, 2012
Abstract:
A biomimetic synthesis of the biologically active ascidian metabolites thiaplidiaquinones A and B is described. Reaction of geranylbenzoquinone with Et(3)N in CH(2)Cl(2) yielded two isomeric quinones, comprising the benzo[c]chromene-7,10-dione core of the natural products. Subsequent reaction with hypotaurine yielded the title compounds and their dioxothiazino regioisomers.
