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Neonectrolide A, a new oxaphenalenone spiroketal from the fungus Neonectria sp
Jinwei Ren1, Fan Zhang, Xiangyu Liu
1State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
Abstract:
Neonectrolide A (1), an oxaphenalenone spiroketal with the previously undescribed (5,8'-dimethyl-5'-oxo-3a',4,5,5'-tetrahydro-3H,3'H-spiro[furan-2,2'-isochromeno[3,4,5-def]chromene]-3'-yl)but-3-enoic acid skeleton, was isolated from cultures of the fungus Neonectria sp. Its absolute configuration was assigned by electronic circular dichroism (ECD) calculations. The skeleton of an oxaphenalenone fused with a 1,6-dioxaspiro[4.5]decane moiety in 1 could be derived from the coisolated putative precursors, corymbiferan lactone E (2) and 3-dehydroxy-4-O-acetylcephalosporolide C (3).
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Fungal Phylum Microsporidia
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