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Published on: January 13, 2017
A new chlorinated diphenyl ether and five known polyketide metabolites from Penicillium griseofulvum cib-119
Feng Zhan1, Tao Yang, Yong-Ping Han
1Ethnic Pharmaceutical Institute of College of Southwest University for Nationalities, Chengdu, 610041, P. R. China.
Abstract:
A series of polyketide metabolites (1-6), including a new chlorinated diphenyl ether (4-chloro-7,4'-dihydroxy-5,2'-dimethoxy-2-methylformate-6'-methybenzophone, 1), were isolated from the solid-fermented rice culture of Penicillium griseofulvum cib-119. The structure of compound 1 was determined on the basis of NMR spectra and single-crystal X-ray diffraction analyses. In addition, compound 1 showed weak cytotoxic activity against prostatic carcinoma cell (PC-3). Compounds 3-5 exhibited significant antimicrobial activities against Staphylococcus aureus and Bacillus subtilis.
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