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YB-1: oncoprotein, prognostic marker and therapeutic target?
Annette Lasham1, Cristin G Print, Adele G Woolley
1Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. a.lasham@auckland.ac.nz
The Biochemical Journal
|December 11, 2012
Summary
The multifunctional protein Y-box-binding protein 1 (YB-1) facilitates key cancer hallmarks, influencing proliferation, immortality, and metastasis. YB-1 shows potential as a cancer progression marker and therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- The "hallmarks of cancer" describe essential biological capabilities acquired by tumor cells.
- The Y-box-binding protein 1 (YB-1) is a multifunctional protein implicated in various cellular processes.
Purpose of the Study:
- To review and evaluate the literature on YB-1's role in facilitating cancer hallmarks.
- To assess YB-1 as a potential biomarker for cancer progression and a therapeutic target.
Main Methods:
- Literature review and analysis of existing studies.
- Examination of YB-1's regulatory functions in cellular signaling pathways related to cancer hallmarks.
Main Results:
- YB-1 modulates proliferation, cell-cycle checkpoints, replicative immortality, and genomic instability.
- YB-1 influences angiogenesis, invasion, metastasis, and inflammation.
- Evidence suggests YB-1 is a marker of cancer progression.
Conclusions:
- YB-1 plays a significant role in multiple cancer hallmarks.
- YB-1 is a promising molecular marker for clinical use in cancer progression.
- YB-1 represents a potential therapeutic target for cancer treatment.
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