Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intestinal Obstruction I: Introduction01:29

Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ChatGPT as a Postoperative Tool Following Lower Lid Blepharoplasty.

Ophthalmic plastic and reconstructive surgery·2025
Same author

Exploring the role of orbital exenteration in survival among patients with severe rhino-orbital cerebral mucormycosis: a case series.

Frontiers in ophthalmology·2025
Same author

Health-Related Quality-of-Life Outcomes for Upper Blepharoplasty and Blepharoptosis Surgery: A Report by the American Academy of Ophthalmology.

Ophthalmology·2025
Same author

Identifying Minimum Single Dose of Recombinant Human Hyaluronidase for In Vitro Dissolution of Twenty-Two Hyaluronic Acid Fillers.

Ophthalmic plastic and reconstructive surgery·2025
Same author

Pharmacologic Agents Used in the Assessment or Correction of Blepharoptosis: A Report by the American Academy of Ophthalmology.

Ophthalmology·2025
Same author

Reconstruction of Bilateral Upper Eyelid Colobomas Using a Vertical Temporal Advancement Flap.

Ophthalmic plastic and reconstructive surgery·2025

Related Experiment Video

Updated: May 16, 2026

A Mouse Model of Intestinal Partial Obstruction
07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Canalicular obstruction: a histopathologic case series.

Kelly R Everman1, Craig N Czyz, Kevin Kalwerisky

  • 1Department of Ophthalmology, The Ohio State University, and Department of Ophthalmology, Oral and Maxillofacial Surgery, Grant Medical Center, Columbus, Ohio 43215, USA.

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|December 11, 2012
PubMed
Summary

Canalicular trephination for epiphora revealed nonspecific inflammation and fibrosis as common causes of blockage. Other findings included sebaceous gland adenoma, muscle, fat, and bone, suggesting varied obstruction origins.

More Related Videos

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Related Experiment Videos

Last Updated: May 16, 2026

A Mouse Model of Intestinal Partial Obstruction
07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Area of Science:

  • Ophthalmology
  • Pathology
  • Surgical Anatomy

Background:

  • Symptomatic epiphora can result from canalicular obstruction.
  • Canalicular trephination is a surgical approach to address these obstructions.
  • Histopathologic analysis of retrieved tissue can elucidate underlying causes.

Purpose of the Study:

  • To investigate the histopathologic causes of canalicular obstruction.
  • To analyze tissue samples obtained during canalicular trephination.
  • To correlate histopathologic findings with clinical presentation and outcomes.

Main Methods:

  • Retrospective chart review of 12 patients undergoing unilateral canalicular trephination.
  • Tissue retrieval from the trephine lumen for pathologic analysis.
  • Confirmation of obstruction via probing and irrigation; concomitant dacryocystorhinostomy in 6 cases.

Main Results:

  • Nonspecific inflammation with associated fibrosis was the most frequent histopathologic finding.
  • Identified tissues included sebaceous gland adenoma, skeletal muscle, adipose tissue, and bone.
  • Findings suggest potential causes for reduced canalicular diameter or architectural distortion.

Conclusions:

  • Canalicular trephination provides diagnostic tissue for histopathologic evaluation of obstructions.
  • Nonspecific inflammation and fibrosis are common findings.
  • The presence of unusual tissues warrants consideration of differential diagnoses, including tumors.