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Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

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Bioactive glasses-incorporated, core-shell-structured polypeptide/polysaccharide nanofibrous hydrogels.

Jian Chen¹, Xiaoyi Chen, Xianyan Yang

¹Department of Surgery, The 2nd Affiliated Hospital, Zhejiang University of School of Medicine, Hangzhou 310009, China.

Carbohydrate Polymers

|December 11, 2012

Summary

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Researchers developed a novel nanofibrous composite hydrogel using gelatin and bioactive glass. This advanced wound healing material mimics natural tissue structure, improving stability for chronic wound treatment.

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Synthetic hydrogels accelerate wound healing but face challenges in nanoscale inorganic-organic hybrid formation.
Brittleness and poor wet-state stability hinder nanofibrous hydrogel applications.

Purpose of the Study:

To develop a stable, nanofibrous inorganic-organic hybrid hydrogel for enhanced wound healing.
To mimic the natural soft tissue nanostructure and composition.

Main Methods:

Fabrication of nanofibrous gelatin/bioactive glass (NF-GEL/BG) composite hydrogel via phase separation.
Stabilization of the nanofiber network using counterionic chitosan-hyaluronic acid pairs.

Main Results:

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Last Updated: May 16, 2026

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

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Published on: November 11, 2022

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

The composite hydrogel exhibits improved microstructural and thermal integrity.

Controlled inorganic ion release was achieved without significant structure collapse.

The hydrogel closely biomimics the fibrous nanostructure of natural soft tissues.

Conclusions:

The developed polysaccharide-crosslinked bioactive hydrogel offers a promising biomaterial for chronic wound treatment.
This material addresses the limitations of existing nanofibrous hydrogels, enhancing stability and mimicking native tissue.