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Published on: February 22, 2020
A novel green gelatin-agar microencapsulation system with P. urinaria as an improved anti-A. niger model
Pik-Ling Lam1, Stanton Hon-Lung Kok, Yiu-Wah Ho
1Institute of Textiles and Clothing and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
Abstract:
In this study, a novel green microencapsulation system was used to develop Phyllanthus urinaria (PU) extract containing microcapsules. Agar was used with gelatin as the wall matrix materials of microcapsules to prevent the use of toxic crosslinker formaldehyde. Microencapsulated PU extract was developed to improve the potential antifungal activities of PU water extracts. The active components and surface morphology of PU extract containing microcapsules were analyzed by liquid chromatography/mass spectrometry and scanning electron microscopy, respectively. The in vitro release study demonstrated that approximately 80% of drug was released after 120 h. PU loaded microcapsules were shown to have a stronger anti-Aspergillus niger activity than the free drug.
