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An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
Published on: April 23, 2018
Cutaneous intraneural perineurioma: a case report
Angel Santos-Briz1, Elena Godoy, Javier Cañueto
1Department of Pathology, Hospital Universitario de Salamanca, Salamanca, Spain. santosbriz@usal.es
The American Journal of Dermatopathology
|December 11, 2012
Summary
This study reports the first case of a cutaneous intraneural perineurioma, a rare benign nerve sheath tumor. The findings expand the known variations of skin lesions involving neural cells.
Area of Science:
- Dermatopathology
- Neurosurgery
- Oncology
Background:
- Perineuriomas are benign neoplasms originating from perineurial cells.
- They are typically classified as either intraneural or extraneural.
- Intraneural perineuriomas commonly affect major nerve trunks, potentially causing neurological deficits.
Observation:
- A case of a 42-year-old male with a lesion on the second finger of the right hand is presented.
- The lesion exhibited a plexiform dermal pattern with enlarged nerve fascicles.
- Histological analysis revealed spindle perineurial cell proliferation in onion-bulb-like formations.
Findings:
- Immunohistochemistry showed positive membranous staining for epithelial membrane antigen and negative S100 protein.
- Fluorescence in situ hybridization indicated loss of a chromosome 22 signal in a subset of cells.
- This represents the first documented instance of a cutaneous intraneural perineurioma.
Implications:
- This case expands the recognized clinicopathologic spectrum of cutaneous neural tumors.
- It highlights the importance of considering rare perineurioma variants in dermatopathology diagnoses.
- Further research may clarify the specific characteristics and behavior of cutaneous intraneural perineuriomas.
