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Updated: May 16, 2026
07:01
Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
Published on: March 1, 2020
CD147 in ovarian and other cancers
1Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. yanghong@fmmu.edu.cn
Summary
CD147, a protein overexpressed in ovarian cancer, promotes tumor progression, invasion, and metastasis. It shows potential as a biomarker for poor prognosis and early diagnosis in ovarian cancer patients.
Area of Science:
- Gynecological Oncology
- Molecular Oncology
Background:
- Ovarian cancer is a leading cause of cancer death in women globally.
- Poor survival rates are linked to late diagnosis, metastasis, and drug resistance.
- There is a critical need for reliable predictive and prognostic markers.
Purpose of the Study:
- To review the roles of CD147 in ovarian cancer progression.
- To discuss the diagnostic and prognostic value of CD147 in ovarian cancer.
Main Methods:
- Literature review of CD147's function in ovarian cancer.
- Analysis of CD147's association with clinical outcomes.
Main Results:
- CD147 is overexpressed in ovarian cancers and linked to poor outcomes.
- CD147 promotes ovarian cancer progression, invasion, metastasis, survival, angiogenesis, and drug resistance.
- CD147 may serve as a potential biomarker for ovarian cancer.
Conclusions:
- CD147 plays a significant role in multiple facets of ovarian cancer malignancy.
- CD147 holds promise as a diagnostic and prognostic biomarker.
- Combination of CD147 with other markers may enhance diagnostic accuracy.
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