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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 16, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Ocular metastases.

V M L Cohen1

  • 1Ocular Oncology Service, Moorefield's and St Bartholomew's Hospital, London, UK. victoria.cohen@bartshealth.nhs.uk

Eye (London, England)
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Ocular metastases, often from lung cancer, can be detected by ophthalmologists. Management focuses on quality of life and visual acuity, considering long-term treatment effects.

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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

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Last Updated: May 16, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • The eye rarely develops disseminated malignancy due to its lack of a lymphatic system.
  • Ocular metastases primarily occur through hematogenous spread, affecting well-vascularized eye structures.
  • Early lung cancer metastasis to the uveal tract can present as the initial sign of advanced disease.

Purpose of the Study:

  • To present the diagnosis and management challenges of ocular metastases.
  • To highlight the ophthalmologist's role in identifying terminal metastatic disease.
  • To discuss treatment strategies aimed at improving quality of life and visual acuity.

Main Methods:

  • Review of cases and diagnostic approaches for ocular metastases.
  • Discussion of treatment options for ocular metastases.
  • Consideration of long-term side effects in the context of improving patient life expectancy.

Main Results:

  • Ocular metastases are rare but can be the first indicator of advanced cancer, particularly lung cancer.
  • The uveal tract is a common site for ocular metastases due to its rich vascular supply.
  • Management strategies prioritize quality of life and visual preservation.

Conclusions:

  • Ophthalmologists play a crucial role in the early detection of disseminated malignancy.
  • Effective management requires a multidisciplinary approach, balancing treatment efficacy with quality of life.
  • Advances in systemic cancer treatment necessitate careful consideration of long-term ocular health.