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Updated: May 16, 2026

Fabrication of polydimethylsiloxane (PDMS)-Based Flexible Surface-Enhanced Raman Scattering (SERS) Substrate for Ultrasensitive Detection
Published on: November 17, 2023
Controllable and reproducible construction of a SERS substrate and its sensing applications
Yongqiang Wen1, Wenqian Wang, Zhiliang Zhang
1Research Center for Bioengineering & Sensing Technology, University of Science and Technology Beijing, Beijing 100083, China. wyq_wen@ustb.edu.cn
Abstract:
A simple method for the preparation of a highly stable and reliable surface-enhanced Raman scattering (SERS) substrate was proposed. The SERS enhancement was demonstrated with good controllability and reproducibility through the controlled formation/deformation of SERS "hotspots" using a reversible DNA nanoswitch. Highly effective DNA detection was achieved using a well-designed sandwich structure.
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