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Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays
Claudio Parolo1, Mariana Medina-Sánchez, Alfredo de la Escosura-Muñiz
1Nanobioelectronics & Biosensors Group, Institut Català de Nanotecnologia, CIN2 (ICN-CSIC), Campus UAB, Barcelona, Spain.
Abstract:
Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results.
