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Updated: May 16, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
Update on the angiotensin AT(2) receptor.
Claudia A McCarthy1, Robert E Widdop, Kate M Denton
1Department of Pharmacology, Monash University, Clayton, Victoria, Australia. claudia.mccarthy@monash.edu
Activation of the angiotensin II type 2 receptor (AT2R) shows therapeutic potential for organ protection, particularly in the heart, kidney, and brain. Novel AT2R ligands like C21 are being investigated for cardiovascular diseases.
Area of Science:
- Cardiovascular Research
- Pharmacology
Background:
- The angiotensin II type 2 receptor (AT2R) counter-regulates AT1R overactivity in pathological states.
- Novel AT2R ligands, including compound 21 (C21), are emerging as potential therapeutics.
Purpose of the Study:
- To review recent evidence on AT2R's organ protective effects.
- To discuss the influence of inflammation and gender on AT2R outcomes.
- To address controversies surrounding C21 and highlight AT2R's role in cardiovascular diseases.
Main Methods:
- Literature review of recent studies on AT2R.
- Analysis of data concerning AT2R ligands and their effects.
- Focus on cardiovascular, renal, and neurological applications.
Main Results:
- AT2R activation demonstrates organ protection in the heart, kidney, and brain.
- Inflammation and gender significantly impact AT2R-mediated outcomes.
- Despite scrutiny of C21, substantial evidence supports AT2R's role in cardiovascular diseases.
Conclusions:
- AT2R activation presents a promising therapeutic strategy for organ protection.
- Further research is needed to clarify the role of AT2R and its ligands in various pathological conditions.
- The field requires continued investigation to resolve controversies and optimize therapeutic applications.
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