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Failure to find interference between anti-HLA antibodies and chlorpromazine
R C Alexander1, M A Coggiano, R J Wyatt
1Neuropsychiatry Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032.
Biological Psychiatry
|March 15, 1990
Abstract:
Chlorpromazine has been reported to interfere with the action of alloantibodies directed against HLA-A1. We attempted to replicate this finding using peripheral blood lymphocytes from 3 healthy donors in a complement-mediated lymphocytotoxicity assay. We were unable to find evidence of interference between chlorpromazine and the anti-HLA sera tested. Possible reasons for the difference between our finding and the previous report, as well as the implications for schizophrenia, are discussed.