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Updated: May 16, 2026
09:10
A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
Published on: May 22, 2018
iPiG: integrating peptide spectrum matches into genome browser visualizations.
Mathias Kuhring1, Bernhard Y Renard
1Research Group Bioinformatics, NG4, Robert Koch-Institute, Berlin, Germany.
Plos One
|December 11, 2012
Summary
Integrating proteomic and genomic data is challenging. We developed iPiG, a tool to visualize mass spectrometry peptide identifications within genome browsers, simplifying comparative analysis.
Area of Science:
- Proteomics
- Genomics
- Bioinformatics
Background:
- Proteogenomic approaches integrate proteomic and genomic data.
- Integrating mass spectrometry identifications with genomic data is difficult due to format discrepancies.
Purpose of the Study:
- Introduce iPiG, a novel tool for integrating peptide identifications from mass spectrometry into genome browser visualizations.
- Simplify concurrent analysis of proteomic and genomic data.
Main Methods:
- iPiG is implemented in Java.
- It functions as a stand-alone tool with a graphical user interface.
- Can be integrated into existing bioinformatics workflows.
Main Results:
- iPiG facilitates direct comparison of proteomic results with genomic data.
- Enables visualization of mass spectrometry identifications within genome browsers.
Conclusions:
- iPiG simplifies the integration and analysis of proteogenomic data.
- The tool enhances the utility of mass spectrometry in genomic contexts.
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