Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer.

Science immunology·2026
Same author

IL-7/IL-15/IL-21 cytokine-fusion scaffold generates highly functional CAR T cells enriched in long-lived T memory stem cells.

Science advances·2026
Same author

Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors.

Signal transduction and targeted therapy·2025
Same author

Retraction of Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.

The Journal of clinical investigation·2025
Same author

Secretogranin 2 binds LILRB4 resulting in immunosuppression.

Nature immunology·2025
Same author

A Switch Protein Adapter for Anti-LILRB4 CAR-T Cells.

European journal of immunology·2024
Same journal

Therapy-related B-cell acute lymphoblastic leukemia after treatment for multiple myeloma.

American journal of blood research·2026
Same journal

Venetoclax-based low-intensity therapy in pediatric AML: A viable option for chemotherapy-intolerant patients.

American journal of blood research·2026
Same journal

Immunological, hematological and biochemical benefits of adjuvant nigella sativa to pharmacotherapy in immune thrombocytopenic purpura patients.

American journal of blood research·2026
Same journal

Incidence and mortality of heparin-induced thrombocytopenia in critically Ill patients.

American journal of blood research·2026
Same journal

Is the coexistence of diabetes and hypertension liable for a higher risk of cardiovascular disorders among Saudis?

American journal of blood research·2026
Same journal

Assessing glucose 6-phosphate dehydrogenase activity in children with acute lymphoblastic leukemia and its relationship to disease activity.

American journal of blood research·2025
See all related articles

Related Experiment Video

Updated: May 16, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

Hematopoietic stem cells: interplay with immunity.

Cheng Cheng Zhang1

  • 1Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

American Journal of Blood Research
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cells (HSCs) sense immune signals to regulate self-renewal and differentiation. HSCs also provide immune inhibitory signals to evade immune attack, revealing a dual role in immunity.

Keywords:
CD274CD47Hematopoietic stem cellsLILRB2PIR-Bimmune inhibitory receptorsimmune privilegeimmunityinfectioninflammation

More Related Videos

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

Related Experiment Videos

Last Updated: May 16, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

Area of Science:

  • Immunology
  • Hematology
  • Stem Cell Biology

Background:

  • Hematopoietic stem cells (HSCs) are known to receive immune signals influencing their behavior.
  • Emerging evidence suggests HSCs possess immune-privileged status within the bone marrow niche.
  • HSCs may actively suppress immune responses through surface molecules.

Purpose of the Study:

  • To explore the bidirectional communication between HSCs and the immune system.
  • To investigate how HSCs act as both signal receivers and providers.
  • To understand the mechanisms by which HSCs evade immune surveillance.

Main Methods:

  • Review of existing evidence on HSC-immune interactions.
  • Analysis of signaling pathways involved in HSC self-renewal and differentiation.
  • Examination of surface molecules expressed by HSCs.

Main Results:

  • HSCs receive external immune signals via surface receptors, modulating their functions.
  • HSCs present inhibitory molecules on their surface, suppressing innate and adaptive immunity.
  • HSCs demonstrate a dual role: sensing immune cues and actively modulating immune responses.

Conclusions:

  • HSCs interact with the immune system as both signal receivers and providers.
  • This bidirectional communication is crucial for HSC survival and function.
  • Further research into HSC-immune interplay may establish a new field: stem cell immunology.