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Updated: May 16, 2026

A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters
Published on: April 20, 2015
"Unclosed cryptands": a point of departure for developing potent neutral anion receptors
Kajetan Dąbrowa1, Marcin Pawlak, Piotr Duszewski
1Institute of Organic Chemistry, Polish Academy of Science, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Abstract:
Six macrocyclic lariat-type compounds, representing a new class of anion receptors, were synthesized in a simple approach. We identified the optimal macroring size and the position of the hydrogen bond donating center in the lariat arm offering the best affinities toward chloride and carboxylate anions. The anion-binding properties of such systems were investigated by applying (1)H NMR titrations in DMSO/water and methanol/DMSO mixtures.
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