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Updated: May 16, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Hypercholesterolemia links hematopoiesis with atherosclerosis
Oliver Soehnlein1, Filip K Swirski
1Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands. oliver.soehnlein@gmail.com
Trends in Endocrinology and Metabolism: TEM
|December 12, 2012
Summary
Atherosclerosis involves lipid and leukocyte buildup in arteries. New research links cholesterol metabolism to inflammation, suggesting new cardiovascular disease treatments targeting this connection.
Area of Science:
- Cardiovascular Science
- Immunology
- Metabolic Research
Background:
- Atherosclerosis involves lipid and leukocyte accumulation in arterial walls.
- Foam cells, derived from lipid-laden leukocytes, contribute to atherosclerotic lesion cores.
- Systemic hypercholesterolemia is linked to increased neutrophils and monocytes in experimental models.
Purpose of the Study:
- To review studies connecting metabolism and inflammation in atherosclerosis.
- To explore how cholesterol-sensing pathways influence hematopoietic stem cell progenitors.
- To propose therapeutic strategies targeting the metabolism-inflammation axis for cardiovascular disease.
Main Methods:
- Review of existing scientific literature.
- Analysis of experimental models of hypercholesterolemia.
- Examination of cholesterol-sensing pathways in hematopoiesis.
Main Results:
- Cholesterol metabolism significantly influences inflammatory processes in atherosclerosis.
- Cholesterol-sensing pathways regulate the proliferation of hematopoietic stem cell progenitors.
- Interactions between lipids and leukocytes are crucial in atheroma development.
Conclusions:
- The link between metabolism and inflammation is a key factor in cardiovascular disease pathogenesis.
- Targeting the cholesterol-inflammation axis offers potential therapeutic avenues for atherosclerosis.
- Further research into this axis could lead to novel treatments for cardiovascular conditions.
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