Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postischemic glucose utilization in rat hippocampal layers.

T Beck1, A Wree, A Schleicher

  • 1Institut für Pharmakologie und Toxikologie, Philipps-Universität, Marburg, F.R.G.

Brain Research
|February 26, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Collapse of Nuclear Collectivity along the N=Z Line.

Physical review letters·2026
Same author

Detailed View at Magnetic Dipole Strengths: The Case of Semimagic ^{50}Ti.

Physical review letters·2026
Same author

Deviations from the Porter-Thomas Distribution due to Nonstatistical γ Decay below the ^{150}Nd Neutron Separation Threshold.

Physical review letters·2025
Same author

Gamma Decay of the ^{154}Sm Isovector Giant Dipole Resonance: Smekal-Raman Scattering as a Novel Probe of Nuclear Ground-State Deformation.

Physical review letters·2025
Same author

A resonant sextuplet of sub-Neptunes transiting the bright star HD 110067.

Nature·2023
Same author

Prediction of exercise respiratory limitation from pulmonary function tests.

Pulmonology·2023

Forebrain ischemia in rats increased hippocampal glucose utilization in the CA1 sector, despite neuronal damage. This suggests hypermetabolism and hyperexcitation correlate with brain injury.

Area of Science:

  • Neuroscience
  • Cerebrovascular Biology
  • Metabolism

Background:

  • Forebrain ischemia can cause significant neuronal damage.
  • Understanding the metabolic changes post-ischemia is crucial for developing therapeutic strategies.
  • The hippocampus is particularly vulnerable to ischemic injury.

Purpose of the Study:

  • To investigate the impact of forebrain ischemia on hippocampal glucose utilization.
  • To determine if metabolic changes correlate with neuronal damage in specific hippocampal subregions.

Main Methods:

  • Forebrain ischemia was induced in male Wistar rats by clamping carotid arteries and reducing blood pressure.
  • Local cerebral glucose utilization (LCGU) was measured 7 days after ischemia.
  • Histological techniques were used to assess neuronal damage.

Related Experiment Videos

Main Results:

  • LCGU was significantly increased in the CA1 sector (pyramidal and radiatum layers) 7 days post-ischemia.
  • LCGU was reduced in CA2, CA3, CA4 sectors, and the dentate gyrus compared to controls.
  • Histological analysis confirmed severe neuronal damage, particularly in the CA1 sector.

Conclusions:

  • Increased LCGU in the CA1 sector suggests long-lasting hyperexcitation.
  • Cellular hypermetabolism in the CA1 sector is implicated in neuronal damage following ischemia.
  • Metabolic alterations provide insights into the pathophysiology of ischemic brain injury.