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Related Experiment Videos

Urinary hydroxyproline in infants with and without fractures/rickets.

W W Koo1, S K Krug Wispe, P Succop

  • 1Department of Pediatrics, University of Alberta Hospitals, Walter Mackenzie Health Science Centre, Edmonton, Canada.

Clinical Chemistry
|April 1, 1990
PubMed
Summary

The urinary peptide-bound hydroxyproline to creatinine ratio is highest in early infancy for very-low-birthweight infants but not sufficient alone for detecting fractures or rickets. Bone turnover markers vary widely in these infants.

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Area of Science:

  • Biochemistry
  • Pediatrics
  • Neonatology

Background:

  • Very-low-birthweight (VLBW) infants are susceptible to bone complications.
  • Assessing bone turnover is crucial for managing VLBW infants.

Purpose of the Study:

  • To measure urinary hydroxyproline to creatinine ratios in VLBW infants.
  • To investigate the utility of these ratios in detecting fractures and rickets (F/R).

Main Methods:

  • Urine samples were collected from VLBW infants at 3, 6, 9, and 12 months.
  • Molar ratios of peptide-bound and free hydroxyproline to creatinine (OHPr:Cr) were analyzed.
  • Infants were categorized into groups with (A) and without (B) F/R.

Main Results:

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  • Both peptide-bound and free OHPr:Cr ratios were highest at three months of age in both groups.
  • Ratios decreased with postnatal age but showed no significant differences between groups.
  • Wide variations in peptide-bound OHPr:Cr ratios were observed within groups.

    • Conclusions:

    • Urinary peptide-bound OHPr:Cr indicates high bone turnover in early infancy for VLBW infants.
    • This ratio alone is insufficient for detecting F/R in VLBW infants.
    • The decrease in free OHPr:Cr ratio may reflect renal tubular function maturation.