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Effect of strontium ranelate on bone remodeling
Juliana Rodríguez1, Natalia D Escudero, Patricia M Mandalunis
1Department of Histology and Embryology, School of Dentistry, University of Buenos Aires, Argentina. juliana_r2@yahoo.com
Acta Odontologica Latinoamericana : AOL
|December 13, 2012
Summary
Strontium ranelate (SrR) did not alter key bone remodeling parameters in healthy Wistar rats over 30 weeks. This study suggests SrR may not impact bone health in non-osteoporotic models.
Area of Science:
- Bone biology and osteoporosis research.
- Pharmacological effects on skeletal tissue.
Background:
- Osteoporosis involves bone microarchitecture deterioration and mass loss.
- Strontium ranelate (SrR) is a treatment for osteoporosis, potentially acting anabolically and anti-catabolically.
- The precise mechanism of action for SrR remains unclear.
Purpose of the Study:
- To investigate the impact of strontium ranelate (SrR) on bone remodeling processes.
- To evaluate SrR's effects in a healthy rodent model.
Main Methods:
- Female Wistar rats were given SrR in drinking water for 30 weeks.
- Histological analysis of jaw and tibia bone samples.
- Histomorphometric evaluation of bone volume, formation, quiescence, resorption, cartilage thickness, and megakaryocytes.
Main Results:
- No significant differences were observed in evaluated bone parameters between SrR-treated rats and controls.
- Bone volume, formation, resorption, cartilage zones, and megakaryocyte counts remained unchanged.
Conclusions:
- Strontium ranelate (SrR) did not demonstrate a significant effect on the studied bone remodeling parameters in healthy Wistar rats.
- These findings suggest SrR may not influence bone turnover in a healthy skeletal state under the experimental conditions.
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