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Published on: July 19, 2013
Free-breathing MOLLI: application to myocardial T(1) mapping
Jyun-Ming Tsai1, Teng-Yi Huang, Yu-Shen Tseng
1Department of Electrical Engineering, National Taiwan University of Science and Technology, Taiwan, Republic of China.
Purpose:
Of the myocardial T(1) mapping techniques, the modified Look-Locker inversion recovery (MOLLI) sequence is accurate and highly reproducible. The MOLLI sequence requires patients to hold their breath for 17 heartbeats during the scanning process to minimize respiratory motion-related artifacts. However, some patients are unable to hold their breath because of illness or limited breath-hold capacity. This study, therefore, aimed to develop a robust myocardial T(1) mapping method based on the MOLLI sequence for patients unable to perform voluntary breath-holds.
Methods:
This study presents a free-breathing MOLLI (FB-MOLLI) sequence and an optimized reconstruction method to allow myocardial T(1) mapping in vivo without breath-hold. Nine healthy volunteers participated in this study after providing institutionally approved consent. The FB-MOLLI sequence acquires 20 images within 29 heartbeats. The reconstruction program employs a two-step automatic image registration technique and an image selection method inspired by the self-gating cardiac imaging method.
Results:
Results indicate that the proposed reconstruction method increases the accuracy and reproducibility of free-breathing T(1) measurements significantly (p < 0.001).
Conclusions:
The FB-MOLLI method provides a robust tool for clinical application in free-breathing myocardial T(1) mapping, and could greatly facilitate acquisition procedures during routine examinations.
