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Updated: May 16, 2026
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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
International Paediatric Stroke Study: stroke associated with cardiac disorders
Michael M Dowling1, Linda S Hynan, Warren Lo
1The University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, TX, USA.
Summary
Pediatric arterial ischemic stroke is often linked to cardiac disorders. Children with cardiac issues had similar symptoms but were younger and had more bilateral strokes, indicating a distinct "cardioembolic stroke pattern".
Area of Science:
- Neurology
- Pediatrics
- Cardiology
Background:
- Arterial ischemic stroke (AIS) in children has diverse causes, frequently involving cardiac disorders.
- Understanding the specific characteristics of AIS in children with cardiac conditions is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the clinical and radiographic differences in pediatric AIS between children with and without cardiac disorders.
- To test the hypothesis that these features differ significantly based on the presence of cardiac etiologies.
Main Methods:
- Analysis of a prospective cohort from the International Paediatric Stroke Study.
- Comparison of clinical presentations, imaging findings, and early outcomes in children with AIS, stratified by the presence of cardiac disorders.
Main Results:
- Cardiac disorders were identified in 30.6% of 667 pediatric AIS cases.
- Children with cardiac disorders were younger (median 3.1 vs. 6.5 years) and less likely to report headache.
- Imaging revealed differences in vascular distribution, with more bilateral strokes and hemorrhagic conversion in the cardiac group.
Conclusions:
- Cardiac disorders are a significant cause of pediatric AIS, affecting nearly one-third of cases.
- While clinical presentations are largely similar, age and headache prevalence differ.
- A distinct 'cardioembolic stroke pattern' is observed in children with cardiac disorders, characterized by bilateral involvement and increased hemorrhagic transformation.
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