Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current strategic trends in drug discovery: the present as prologue.

Expert opinion on drug discovery·2023
Same author

Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure.

Bioorganic & medicinal chemistry·2021
Same author

Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy.

Journal of medicinal chemistry·2021
Same author

Tackling the reproducibility problem to empower translation of preclinical academic drug discovery: is there an answer?

Expert opinion on drug discovery·2021
Same author

Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility.

Bioorganic & medicinal chemistry·2020
Same author

Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.

Journal of medicinal chemistry·2019

Related Experiment Video

Updated: May 16, 2026

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening
05:54

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

Published on: September 5, 2018

Developing doctoral scientists for drug discovery: pluridimensional education required.

David R Janero

    Expert Opinion on Drug Discovery
    |December 13, 2012
    PubMed
    Summary

    Doctoral science students need broader training beyond lab work for drug discovery careers. Enhancing graduate education with essential professional skills is crucial for therapeutics innovation and career readiness.

    More Related Videos

    In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
    08:04

    In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

    Published on: May 11, 2021

    Related Experiment Videos

    Last Updated: May 16, 2026

    Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening
    05:54

    Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

    Published on: September 5, 2018

    In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
    08:04

    In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

    Published on: May 11, 2021

    Area of Science:

    • Biomedical Sciences
    • Drug Discovery and Development
    • Graduate Education

    Background:

    • Doctoral science students show interest in therapeutics research but lack practical drug discovery and commercialization experience.
    • The traditional academic system (PI-stan) often overlooks the development of "beyond-the-bench" professional skills vital for therapeutics innovation.
    • This can lead to a deficit in professionalization for future drug discovery researchers.

    Discussion:

    • The current academic model risks commoditizing doctoral students as labor, hindering their preparation for careers in therapeutics innovation.
    • There's a critical need for graduate education to incorporate pluridimensionality, extending beyond scientific domains and lab techniques.
    • Mentorship should focus on developing transferable skills like operational intelligence, project/people management, and communication.

    Key Insights:

    • Academic training must evolve to equip doctoral students with essential professional competencies for modern drug discovery.
    • Integrating business acumen and project management into graduate curricula is vital for career adaptability.
    • Bridging the gap between academic research and the commercial drug development landscape is paramount.

    Outlook:

    • Implementing specific initiatives can enhance doctoral students' market competitiveness in preclinical drug discovery R&D.
    • Improved graduate education will better prepare scientists to navigate the complexities of research, commercialization, and occupational challenges.
    • This approach fosters a more adaptable and skilled workforce for the future of therapeutics innovation.