Related Experiment Video
Updated: May 16, 2026
A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
Published on: February 3, 2023
[Effect of Kang'ai injection on hepatic fibrosis in rats]
Xinmei Xie1, Rui Pang, Fanye Zeng
1Xinjiang Medical University of Chinese Medicine Hospital, Urumqi 830000, China. 748215562@qq.com
Objective:
To investigate the inhibition role of Kang'ai injection (KAI) in rats with hepatic fibrosis.
Method:
Animal model with liver fibrosis were induced by 0.01% concentration of diethylnitrosamine (DEN). 30 female Wistar rats (160-200 g) were randomly divided into 3 groups: the KAI-DEN group, the DEN group and the blank control group. The KAI-DEN group was administered Kang'ai injection (1 mL x k(-1), intraperitoneal injection, once a week) and the DEN group was administered normal saline intraperitoneal injection. HE staining and VG special staining of liver tissue were used to evaluate liver fibrosis.
Result:
Compared with the DEN group, relatively less structural damage and less pseudolobular formation in the KAI-DEN group. Collagen area of the blank control group, the KAI-DEN group and the DEN group were (6.52 +/- 2.64)% , (17.41 +/- 1.112)% and (20.180 +/- 2.519)% , respectively. The difference was statistically significant, P < 0.05.
Conclusion:
Kang'ai injection could inhibit the formation of DEN-induced liver fibrosis.
