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[Risk factors for coronary artery lesions in children with Kawasaki disease]

Yan Li1, Xian-Min Wang, Yi-Ling Liu

  • 1Department of Pediatric Cardiology, Chengdu Women and Children's Central Hospital, Chengdu, China. 1983777939@qq.com

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|December 14, 2012
PubMed

Insights

Children with Kawasaki disease (KD) aged under 1 or over 8, males, and those with delayed IVIG treatment face higher risks of coronary artery lesions (CAL). Early IVIG treatment is protective against CAL development in KD patients.

Area of Science:

  • Pediatric Cardiology
  • Immunology
  • Rheumatology

Context:

  • Kawasaki disease (KD) is a leading cause of acquired heart disease in children.
  • Coronary artery lesions (CAL) are the most serious complication of KD.
  • Identifying risk factors for CAL is crucial for timely intervention and management.

Purpose:

  • To investigate the risk factors associated with the development of coronary artery lesions (CAL) in children diagnosed with Kawasaki disease (KD).

Summary:

  • Retrospective analysis of 527 children with KD identified several independent risk factors for CAL.
  • These include younger age (<1 year), older age (>8 years), male sex, incomplete KD, delayed intravenous immunoglobulin (IVIG) treatment (>10 days), non-response to IVIG, and prolonged fever (>10 days).
  • Early IVIG treatment (before 5 days) demonstrated a protective effect against CAL.

Impact:

  • Findings highlight critical demographic and clinical factors influencing CAL development in KD.
  • Informs clinical practice for risk stratification and targeted management strategies in pediatric KD patients.
  • Contributes to understanding KD pathogenesis and improving long-term cardiovascular outcomes in affected children.
Abstract

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