Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Upper Respiratory Drugs: Decongestants01:27

Upper Respiratory Drugs: Decongestants

Decongestants are a class of medications used primarily to alleviate nasal congestion, a common symptom resulting from allergies, colds, sinusitis, and other upper respiratory tract infections. These drugs work by activating α-adrenergic receptors, constricting small blood vessels in the nasal membranes. This action results in the opening of clogged nasal passages, thereby facilitating sinus drainage and relieving congestion.
Most decongestants are readily available over-the-counter in various...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Superior Labial Artery Flap for Septal Perforation Repair: The Boxer's Flap.

The Laryngoscope·2026
Same author

Vietnamese SNOT-22 Validation: Prospective Cohort Study on Sinonasal Symptoms And Health-Related Quality of Life.

OTO open·2026
Same author

Correlation of Patient-Reported Symptoms With Rhinogram Features Beyond Simple Airway Resistance.

The Annals of otology, rhinology, and laryngology·2026
Same author

Treatment Outcomes of Total Versus Superficial Parotidectomy With Postoperative Radiotherapy for High-Grade Parotid Carcinoma Confined to the Superficial Lobe: A Propensity Score-Adjusted Analysis.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2026
Same author

Effect of Preoperative Systemic Steroids on Tissue Eosinophils in CRSwNP: Meta-Analysis.

The Laryngoscope·2026
Same author

Extent of Sinus Surgery Is Associated With Disease Control in Biologic Treated Type 2 Dominant CRS.

International forum of allergy & rhinology·2026

Related Experiment Video

Updated: May 16, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Topical steroids for nasal polyps.

Larry Kalish1, Kornkiat Snidvongs, Rahuram Sivasubramaniam

  • 1Sydney Sinus and Allergy Centre, Suite 206, 203-233 New South Head Road, Edgecliff, NSW, Australia, 2027.

The Cochrane Database of Systematic Reviews
|December 14, 2012
PubMed
Summary
This summary is machine-generated.

Topical corticosteroids effectively treat chronic rhinosinusitis with nasal polyps (CRSwNP), improving symptoms and reducing polyp size. Benefits outweigh risks, even after sinus surgery, though further research is needed.

Related Experiment Videos

Last Updated: May 16, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Area of Science:

  • Otolaryngology
  • Allergy and Immunology
  • Pharmacology

Background:

  • Chronic rhinosinusitis with nasal polyps (CRSwNP) involves nasal mucosa swelling and overgrowth, requiring ongoing management.
  • Topical corticosteroids are a common treatment, but usage varies in dosage, setting, and conjunction with sinus surgery.

Purpose of the Study:

  • To evaluate the efficacy of topical corticosteroids in treating CRSwNP.
  • To analyze treatment effects across patient subgroups based on prior sinus surgery.
  • To determine optimal dosing and delivery methods for topical corticosteroids.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials (RCTs) identified through comprehensive database searches.
  • Forty RCTs involving 3624 patients were included.
  • Data extraction and analysis focused on sino-nasal symptoms, polyp size, and post-surgical polyp recurrence.

Main Results:

  • Topical corticosteroids significantly improved overall symptom scores and reduced polyp size compared to placebo.
  • Treatment led to a higher proportion of patients experiencing symptom improvement and polyp reduction.
  • Topical corticosteroids were effective in preventing polyp recurrence after surgery, with greater benefits observed in patients treated after sinus surgery.

Conclusions:

  • Topical corticosteroids are a beneficial and safe treatment for CRSwNP, with advantages exceeding minor adverse effects.
  • The treatment improves symptoms, decreases polyp size, and prevents recurrence post-surgery.
  • Patients undergoing sinus surgery may experience enhanced benefits from topical corticosteroids, warranting further investigation.