A case of primary cardiac lymphoma mimicking acute coronary and aortic syndrome
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Sung Woo Cho1, Byung Kyu Kim, Jin Tae Hwang
1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea. ; Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Insights
Primary cardiac lymphoma (PCL), a rare but increasing condition, can mimic acute coronary syndromes. This case highlights PCL
Area of Science:
- Cardiology
- Oncology
- Pathology
Background:
- Primary cardiac lymphoma (PCL) is an exceptionally rare malignancy.
- The incidence of PCL is rising, presenting with diverse clinical symptoms.
- PCL can often be misdiagnosed due to its varied presentations.
Purpose of the Study:
- To report a rare case of primary cardiac lymphoma.
- To illustrate the diagnostic challenges and mimicry of PCL with acute coronary and aortic syndromes.
- To emphasize the importance of considering PCL in specific clinical scenarios.
Main Methods:
- Case report of a 51-year-old female.
- Clinical presentation: chest pain radiating to the back.
- Diagnostic workup included electrocardiogram, cardiac troponin-T, chest radiography, and computed tomography scan.
- Histopathological examination of the pericardial mass.
Main Results:
- The patient presented with symptoms mimicking acute coronary and aortic syndromes.
- Diagnostic imaging revealed a large pericardial mass.
- Histopathology confirmed diffuse large B-cell lymphoma.
- The patient succumbed to refractory ventricular tachycardia, likely due to myocardial infiltration.
Conclusions:
- Primary cardiac lymphoma can present insidiously, mimicking common cardiovascular emergencies.
- Early and accurate diagnosis is crucial for appropriate management of PCL.
- Extensive myocardial infiltration by PCL can lead to fatal arrhythmias.
Abstract:
Primary cardiac lymphoma (PCL) is a rare disorder, but the incidence is increasing and its clinical manifestations are various. We report a case of PCL, which mimics an acute coronary and aortic syndrome. A 51 year-old female was presented with chest pain radiating to the back. Her initial electrocardiogram revealed T wave inversion in the leads of V 5-6, II, III and aVF. Additionally, cardiac troponin-T was slightly elevated. Chest radiography showed marked mediastinal widening. Computed tomography scan showed a huge pericardial mass. The histopathologic findings of the mass were compatible with diffuse large B cell lymphoma. She died of refractory ventricular tachycardia, probably, due to an extensive infiltration of PCL to the myocardium.
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