[Indolent CD8+ lymphoid proliferation on the nose]

Area of Science:

• Dermatology
• Oncology
• Immunology

Background:

• Reports a rare cutaneous T-cell lymphoma variant: indolent non-epidermotropic CD8+ lymphoid proliferation of the ear.
• This entity is distinct from previously described cutaneous T-cell lymphomas.

Observation:

• Presents a case of indolent CD8+ lymphoid proliferation involving the nasal crest in an 87-year-old woman.
• The lesion was a pigmented papule present for 9 years with spontaneous regression.
• Histopathology revealed dense dermal lymphoid infiltration with a monomorphous CD8+ lymphocyte population.

Findings:

• The condition is characterized by non-symptomatic infiltrated lesions, often on the ear, potentially bilateral.
• Histological findings can appear concerning due to dense cellular infiltrate.
• Despite worrying histology, the condition typically exhibits indolent progression.

Implications:

• Highlights the importance of recognizing indolent CD8+ lymphoid proliferation as a distinct entity.
• Suggests topical corticosteroids as a potential treatment option.
• Contributes to the understanding of rare lymphoid proliferations in the skin.