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12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Autoimmune progesterone dermatitis].
Z Lahmam Bennani1, N El Fekih, D Baccouche
1Service de dermatologie, faculté de médecine de Tunis, université Tunis el Manar, hôpital Charles-Nicolle, boulevard 9-avril, 1006 Tunis, Tunisie. lzinben@gmail.com
Annales De Dermatologie Et De Venereologie
|December 15, 2012
Summary
Autoimmune progesterone dermatitis (AIPD) is a rare condition causing cyclical skin eruptions due to progesterone sensitivity. Treatment involves suppressing ovulation, leading to symptom resolution.
Area of Science:
- Dermatology
- Immunology
- Endocrinology
Background:
- Autoimmune progesterone dermatitis (AIPD) arises from an immune response to progesterone, often triggered by exogenous sources like contraceptives.
- Cyclical skin eruptions occur during the luteal phase, coinciding with elevated progesterone levels, mimicking other dermatoses.
Observation:
- A 23-year-old woman presented with chronic, pruritic papular-vesicular eruptions since puberty, unresponsive to conventional treatments.
- Lesions exhibited cyclical exacerbation preceding menstruation and resolution post-menstruation.
- Intradermal progesterone testing confirmed the diagnosis of AIPD.
Findings:
- Symptomatic improvement and sustained remission were achieved with oral contraceptives that inhibit ovulation.
- This suggests that suppressing progesterone secretion effectively manages AIPD symptoms.
Implications:
- AIPD diagnosis requires recognizing cyclical skin lesions and response to ovulation inhibition.
- Understanding the unclear pathogenesis, potentially involving antibodies or cell-mediated immunity, is crucial.
- Early diagnosis and management are vital to improve quality of life and prevent severe outcomes.
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