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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

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Updated: May 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

[Autoimmune progesterone dermatitis].

Z Lahmam Bennani1, N El Fekih, D Baccouche

  • 1Service de dermatologie, faculté de médecine de Tunis, université Tunis el Manar, hôpital Charles-Nicolle, boulevard 9-avril, 1006 Tunis, Tunisie. lzinben@gmail.com

Annales De Dermatologie Et De Venereologie
|December 15, 2012
PubMed
Summary
This summary is machine-generated.

Autoimmune progesterone dermatitis (AIPD) is a rare condition causing cyclical skin eruptions due to progesterone sensitivity. Treatment involves suppressing ovulation, leading to symptom resolution.

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

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Last Updated: May 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

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Published on: October 12, 2012

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Area of Science:

  • Dermatology
  • Immunology
  • Endocrinology

Background:

  • Autoimmune progesterone dermatitis (AIPD) arises from an immune response to progesterone, often triggered by exogenous sources like contraceptives.
  • Cyclical skin eruptions occur during the luteal phase, coinciding with elevated progesterone levels, mimicking other dermatoses.

Observation:

  • A 23-year-old woman presented with chronic, pruritic papular-vesicular eruptions since puberty, unresponsive to conventional treatments.
  • Lesions exhibited cyclical exacerbation preceding menstruation and resolution post-menstruation.
  • Intradermal progesterone testing confirmed the diagnosis of AIPD.

Findings:

  • Symptomatic improvement and sustained remission were achieved with oral contraceptives that inhibit ovulation.
  • This suggests that suppressing progesterone secretion effectively manages AIPD symptoms.

Implications:

  • AIPD diagnosis requires recognizing cyclical skin lesions and response to ovulation inhibition.
  • Understanding the unclear pathogenesis, potentially involving antibodies or cell-mediated immunity, is crucial.
  • Early diagnosis and management are vital to improve quality of life and prevent severe outcomes.