Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Pancreas01:19

Pancreas

The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short and...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

OPTN/SRTR 2020 Annual Data Report: Living Donor Collective

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

OPTN/SRTR 2020 Annual Data Report: Introduction.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

OPTN/SRTR 2020 Annual Data Report: VCA.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

OPTN/SRTR 2020 Annual Data Report: Kidney.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

OPTN/SRTR 2020 Annual Data Report: DOD.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022

Related Experiment Video

Updated: May 16, 2026

Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique
13:38

Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique

Published on: June 24, 2022

OPTN/SRTR 2011 Annual Data Report: pancreas.

R Kandaswamy1, P G Stock, M A Skeans

  • 1Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN, USA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|December 15, 2012
PubMed
Summary

Pancreas transplant numbers are down, but patient outcomes are improving for all types, including simultaneous pancreas-kidney, pancreas after kidney (PAK), and pancreas transplant alone (PTA). This trend reflects better donor and recipient selection and surgical techniques.

More Related Videos

Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology
08:16

Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology

Published on: March 15, 2024

Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles
08:04

Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles

Published on: November 3, 2023

Related Experiment Videos

Last Updated: May 16, 2026

Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique
13:38

Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique

Published on: June 24, 2022

Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology
08:16

Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology

Published on: March 15, 2024

Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles
08:04

Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles

Published on: November 3, 2023

Area of Science:

  • Transplantation immunology
  • Organ transplantation outcomes
  • Nephrology and Urology

Background:

  • Pancreas transplant numbers have declined over the last decade.
  • Simultaneous pancreas-kidney transplant, pancreas after kidney (PAK), and pancreas transplant alone (PTA) all show improving outcomes.
  • Decreases in PAK transplants may correlate with reduced living donor kidney transplants.

Purpose of the Study:

  • To analyze trends in pancreas transplantation numbers and outcomes.
  • To identify factors contributing to improved post-transplant results.
  • To highlight challenges in pancreas transplant data interpretation and patient care.

Main Methods:

  • Analysis of national pancreas transplant waiting list data.
  • Review of transplant rates, donor characteristics, and discard rates.
  • Examination of post-transplant outcomes including re-hospitalization and rejection.

Main Results:

  • Pancreas transplant rates decreased to 34.9 per 100 wait-list years in 2011.
  • Organ donor rates declined, but donation after circulatory death increased.
  • Higher discard rates were observed for pancreata from older donors.
  • Improved outcomes are linked to better donor/recipient selection and surgical techniques.
  • High rates of early post-transplant re-hospitalization and rejection, particularly in PTA recipients.

Conclusions:

  • Despite declining numbers, pancreas transplant outcomes are improving due to advancements in selection and technique.
  • Standardizing graft failure definitions is crucial for accurate outcome interpretation.
  • PTA recipients face higher risks of rejection and post-transplant lymphoproliferative disorder.