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Related Concept Videos

Precipitation Processes01:12

Precipitation Processes

The experimental conditions in a gravimetric analysis should be optimized to maximize the particle size and purity of the obtained precipitate. Ideally, the concentration of the precipitating reagent should be low with effective stirring to maintain low relative supersaturation for the growth of large crystals. In homogeneous precipitation, the precipitant is slowly generated by a chemical reaction in the solution to avoid local reagent excesses. For example, urea decomposes gradually to...
Shock Waves01:16

Shock Waves

While deriving the Doppler formula for the observed frequency of a sound wave, it is assumed that the speed of sound in the medium is greater than the source's speed through it. When this condition is breached, a shock wave occurs.
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high pressures...
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Responses to Drought and Flooding

Water plays a significant role in the life cycle of plants. However, insufficient or excess of water can be detrimental and pose a serious threat to plants.
Ecological Disturbance02:26

Ecological Disturbance

An ecological disturbance is a temporary disruption in the environment resulting from abiotic, biotic, or anthropogenic factors, causing a pronounced change in an ecosystem. The impact of an ecological disturbance, which can depend on its intensity, frequency, and spatial distribution, plays a significant role in shaping the species diversity within the ecosystem.
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Precipitation Reactions03:10

Precipitation Reactions

In a precipitation reaction, aqueous solutions of soluble salts react to give an insoluble ionic compound – the precipitate. The reaction occurs when oppositely charged ions in solution overcome their attraction for water and bind to each other, forming a precipitate that separates out from the solution. Since such reactions involve the exchange of ions between ionic compounds in aqueous solution, they are also referred to as double displacement, double replacement, exchange reactions, or...

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Related Experiment Video

Updated: May 16, 2026

Test Samples for Optimizing STORM Super-Resolution Microscopy
16:52

Test Samples for Optimizing STORM Super-Resolution Microscopy

Published on: September 6, 2013

Development in the STORM.

Daichi Kamiyama1, Bo Huang

  • 1Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. daichi.kamiyama@ucsf.edu

Developmental Cell
|December 15, 2012
PubMed
Summary
This summary is machine-generated.

Superresolution microscopy, like stochastic optical reconstruction microscopy/photoactivated localization microscopy (STORM/PALM), offers new developmental biology insights. Challenges include tissue imaging and sample prep, but opportunities for discovery are significant.

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Area of Science:

  • Developmental Biology
  • Microscopy
  • Cell Biology

Background:

  • Superresolution microscopy has revolutionized biological research.
  • Stochastic optical reconstruction microscopy/photoactivated localization microscopy (STORM/PALM) are key superresolution techniques.
  • Developmental biology requires advanced imaging for studying complex processes.

Purpose of the Study:

  • To explore the application of superresolution microscopy in developmental biology.
  • To identify challenges associated with using STORM/PALM in this field.
  • To highlight emerging opportunities for developmental biology research using these advanced imaging methods.

Main Methods:

  • Focus on stochastic optical reconstruction microscopy/photoactivated localization microscopy (STORM/PALM).
  • Analysis of challenges in tissue imaging.
  • Evaluation of sample preparation artifacts and image interpretation issues.

Main Results:

  • Superresolution microscopy presents significant challenges for developmental biology applications.
  • Tissue imaging, sample preparation, and image interpretation are key hurdles.
  • Despite challenges, new opportunities for advancing developmental biology are identified.

Conclusions:

  • Superresolution microscopy, particularly STORM/PALM, holds great potential for developmental biology.
  • Overcoming current technical challenges is crucial for realizing this potential.
  • Further research can leverage these techniques to uncover novel biological insights.