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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Diffusion MRI-based cortical complexity alterations associated with executive function in multiple sclerosis.

Nils Muhlert1, Varun Sethi, Torben Schneider

  • 1NMR Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK. n.muhlert@ucl.ac.uk

Journal of Magnetic Resonance Imaging : JMRI
|December 15, 2012
PubMed
Summary
This summary is machine-generated.

Diffusion orientational complexity (DOC) is a new MRI measure showing decreased frontal cortex activity in multiple sclerosis (MS) patients. This measure aids in understanding MS-related cognitive changes.

Keywords:
DTIHARDIcognitiondiffusion orientational complexitymultiple sclerosis

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Area of Science:

  • Neuroimaging
  • Neurology
  • Biomedical Engineering

Background:

  • Multiple Sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Cognitive impairment is a common symptom in MS patients, impacting daily life.
  • Conventional diffusion MRI measures like MD and FA have limitations in characterizing complex white matter changes.

Purpose of the Study:

  • Introduce diffusion orientational complexity (DOC) as a novel MRI measure.
  • Investigate DOC abnormalities in the frontal and occipital cortex of MS patients.
  • Correlate DOC with conventional diffusion measures (MD, FA) and cognitive function.

Main Methods:

  • High angular resolution diffusion imaging (HARDI) was used to acquire data from 51 MS patients and 28 healthy controls.
  • DOC, mean diffusivity (MD), and fractional anisotropy (FA) were measured in specific cortical regions of interest (ROIs).
  • Regions included frontal cortex (executive function) and occipital cortex (control).

Main Results:

  • Frontal cortex DOC was significantly reduced in MS patients compared to controls.
  • DOC showed distinct correlations with FA and MD in controls versus MS patients.
  • In regression models, frontal cortex DOC and FA independently predicted executive function scores.

Conclusions:

  • Diffusion orientational complexity (DOC) is a novel and valuable MRI measure for assessing cortical pathology in MS.
  • DOC provides complementary information to conventional diffusion measures.
  • DOC may serve as a sensitive biomarker for functionally relevant cortical changes in MS.