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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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Related Experiment Video

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Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation.

Jenna L Wilson¹, Todd C McDevitt

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332-0535, USA.

Biotechnology and Bioengineering

|December 15, 2012

Summary

Cell microencapsulation protects stem cells, enhancing their therapeutic potential. This technique supports stem cell potency, differentiation, and transplantation for treating disorders.

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Published on: March 9, 2012

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Alginate Microcapsule as a 3D Platform for Propagation and Differentiation of Human Embryonic Stem Cells (hESC) to Different Lineages

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Published on: March 9, 2012

Area of Science:

Biomaterials Science
Regenerative Medicine
Cell Therapy Engineering

Background:

Cell microencapsulation shields cells, allowing nutrient and oxygen exchange.
Stem cells are ideal for therapies due to self-renewal and secretion.
Microencapsulation offers a controlled microenvironment for stem cells.

Purpose of the Study:

Review microencapsulation methods for stem cell therapy.
Discuss maintaining stem cell potency and directing differentiation.
Explore scalable production and transplantation strategies.

Main Methods:

Overview of relevant microencapsulation processes.
Characterization techniques for encapsulated stem cells.
Assessment of stem cell behavior within microcapsules.

Main Results:

Microencapsulation protects stem cells from external stress.
Defined microenvironments can modulate stem cell phenotype.
Enables transplantation while preventing immune rejection.

Conclusions:

Microencapsulation is crucial for stem cell therapy development.
Optimized methods are key for maintaining stem cell function.
This approach facilitates clinical translation for various disorders.