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Related Experiment Video

Updated: Jun 24, 2026

Brain Organoid Generation from Induced Pluripotent Stem Cells in Home-Made Mini Bioreactors

Brain Organoid Generation from Induced Pluripotent Stem Cells in Home-Made Mini Bioreactors

Published on: December 11, 2021

Engineering co-emergence in organoid models.

Ivana Vasic^1,2, Todd C McDevitt^1,3,4

¹Gladstone Institutes, San Francisco, CA, United States of America.

Progress in Biomedical Engineering (Bristol, England)

|December 10, 2025

Summary

This summary is machine-generated.

Pluripotent stem cell organoids offer powerful in vitro models for development and disease research. Engineering cooperative emergence addresses variability in stem cell differentiation for improved consistency and control in organoid models.

Keywords:

co-emergence morphogenesis organoids pluripotent stem cells symmetry breaking tissue engineering

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Last Updated: Jun 24, 2026

Brain Organoid Generation from Induced Pluripotent Stem Cells in Home-Made Mini Bioreactors

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Laboratory-Engineered Glioblastoma Organoid Culture and Drug Screening

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Published on: January 10, 2025

Area of Science:

Stem cell biology
Developmental biology
Regenerative medicine

Background:

Pluripotent stem cell-derived organoids are valuable in vitro models for studying development and disease.
Their self-renewal and self-organization capabilities enable the creation of complex multicellular structures.
Clinical translation is hindered by stochastic differentiation, leading to inconsistencies in cell maturity, tissue function, and reproducibility.

Purpose of the Study:

To explore novel approaches for enhancing the consistency and control of organoid models.
To address the challenges posed by stochastic stem cell differentiation in organoid development.
To leverage developmental biology principles for engineering improved organoid systems.

Main Methods:

Utilizing advances in developmental biology to understand pattern formation and symmetry breaking.
Engineering cooperative emergence (co-emergence) strategies within organoid models.
Investigating mechanisms regulating self-organization in three-dimensional stem cell cultures.

Main Results:

New approaches have been developed based on embryonic developmental mechanisms.
These methods aim to engineer cooperative emergence in organoid models.
The goal is to overcome limitations of stochastic differentiation and improve organoid characteristics.

Conclusions:

Engineering cooperative emergence offers a promising strategy to enhance organoid models.
This approach addresses key challenges in stem cell differentiation for improved reproducibility and control.
Advances in developmental biology are crucial for the future of organoid technology and its clinical applications.