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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...

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Related Experiment Video

Updated: May 16, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Hepatitis C screening: getting it right.

Brian R Edlin1

  • 1National Development and Research Institutes, New York, NY 10010, USA. bredlin.nyc@gmail.com

Hepatology (Baltimore, Md.)
|December 15, 2012
PubMed
Summary
This summary is machine-generated.

The U.S. Preventive Services Task Force (USPSTF) should recommend screening for Hepatitis C virus (HCV) in all asymptomatic adults. Current guidelines hinder public health efforts to control the deadliest bloodborne viral disease in the U.S.

Related Experiment Videos

Last Updated: May 16, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Area of Science:

  • Public Health
  • Hepatology
  • Preventive Medicine

Background:

  • Hepatitis C is the most prevalent and deadliest bloodborne viral disease in the United States.
  • The U.S. Preventive Services Task Force (USPSTF) 2004 guideline recommended against screening asymptomatic adults for Hepatitis C.
  • This guideline has impeded public health initiatives for screening, identification, and care of infected individuals.

Purpose of the Study:

  • To examine the USPSTF's guideline development process for Hepatitis C screening.
  • To advocate for updated guidelines that support comprehensive Hepatitis C screening and management.
  • To address the limitations of the current USPSTF recommendations regarding Hepatitis C testing.

Main Methods:

  • Analysis of the USPSTF's guideline development process.
  • Review of evidence regarding the benefits and harms of Hepatitis C screening.
  • Examination of the draft revision of the Hepatitis C guideline released in November 2012.

Main Results:

  • The draft 2012 USPSTF guideline suggests a potential small net benefit for testing individuals born between 1945-1965.
  • The draft guideline falls short of a definitive recommendation for screening this cohort.
  • The current process and recommendations have historically hindered public health efforts against Hepatitis C.

Conclusions:

  • The USPSTF should adopt a balanced approach to evaluating screening benefits and harms.
  • A preponderance of evidence standard is recommended for interventions targeting serious public health issues like Hepatitis C.
  • USPSTF should be transparent about value judgments, consider population-specific disease prevalence, and recommend screening for all asymptomatic adults.