Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Chrysoeriol-Mediated Neuroprotection in Parkinson's Disease in Mice: Targeting Apoptosis, α-Synuclein Accumulation, and Functional Recovery.

The Yale journal of biology and medicine·2026
Same journal

Musicality is Preserved in Neurodegeneration.

The Yale journal of biology and medicine·2026
Same journal

Burden of Neurological Disorders in Resource-Limited Settings: Lessons from Pakistan for Global Neurology.

The Yale journal of biology and medicine·2026
Same journal

Comparative Analysis of Prenatal Stress Models: Placental and Neurodevelopmental Outcomes in Mice.

The Yale journal of biology and medicine·2026
Same journal

Computational Investigation of Flavonoid-Associated Molecular Pathways in Astrogliosis Modulation.

The Yale journal of biology and medicine·2026
Same journal

Regulation and Interaction Among SOCS1 and SOCS3 by MicroRNAs in Multiple Sclerosis: A Review and <i>In Silico</i> Analysis.

The Yale journal of biology and medicine·2026
See all related articles

Related Experiment Video

Updated: May 16, 2026

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
06:50

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

Published on: December 29, 2014

Environmental enrichment: aging and memory.

Toral Rohit Patel1

  • 1University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA. trpatel@uab.edu

The Yale Journal of Biology and Medicine
|December 15, 2012
PubMed
Summary
This summary is machine-generated.

Aging naturally impairs learning and memory, impacting brain function. This study explores how histone acetylation and environmental enrichment influence memory, offering insights for neurodegenerative disease therapies.

Keywords:
HDAC inhibitorsagingenvironmental enrichmenthistone acetylationlearning and memoryneurodegenerative diseases

More Related Videos

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
07:25

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Related Experiment Videos

Last Updated: May 16, 2026

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
06:50

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

Published on: December 29, 2014

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
07:25

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Area of Science:

  • Neuroscience
  • Aging Research
  • Molecular Biology

Background:

  • Normal aging is characterized by a decline in learning and memory, often linked to neurodegenerative diseases like Alzheimer's.
  • Memory loss is an inevitable aspect of aging, prompting research into cortical functions.
  • Histone acetylation and environmental enrichment are known to influence synaptic plasticity, crucial for learning and memory.

Purpose of the Study:

  • To investigate the interaction between environmental enrichment and histone acetylation in the brain.
  • To understand how these mechanisms affect learning and memory processes.
  • To identify potential therapeutic targets for age-related memory decline and neurodegenerative diseases.

Main Methods:

  • The study likely involves molecular and cellular techniques to examine histone acetylation.
  • Behavioral experiments may be used to assess learning and memory in aging models.
  • Neuroimaging or electrophysiological methods could be employed to study synaptic plasticity.

Main Results:

  • Findings indicate that histone acetylation plays a key role in synaptic plasticity and memory formation.
  • Environmental enrichment demonstrates a capacity to enhance memory by stimulating synaptic plasticity.
  • The interplay between these two factors significantly impacts cognitive functions during aging.

Conclusions:

  • Understanding the interaction between histone acetylation and environmental enrichment is vital for cognitive health in aging.
  • These mechanisms offer promising avenues for developing novel therapeutic strategies against dementia and age-related memory deficits.
  • Further research can translate these findings into effective interventions for neurodegenerative conditions.