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[Systemic and oropharyngeal side effects of inhaled corticosteroids]
1Service de médecine interne générale, HUG, 1211 Genève 14. tamara.rochat@hcuge.ch
Revue Medicale Suisse
|December 18, 2012
Summary
Inhaled corticosteroids (ICS) manage asthma by reducing airway inflammation but can cause systemic side effects. Adjusting ICS dosage and type can mitigate these risks.
Area of Science:
- Pulmonology
- Pharmacology
- Endocrinology
Context:
- Inhaled corticosteroids (ICS) are a cornerstone of asthma management, primarily targeting airway inflammation.
- Despite their efficacy, ICS are associated with potential systemic and oropharyngeal side effects.
Purpose:
- To review the systemic and oropharyngeal side effects of inhaled corticosteroids (ICS) in asthma management.
- To discuss factors influencing the occurrence and severity of these side effects.
Summary:
- Systemic side effects include adrenal insufficiency, osteoporosis, skin fragility, ocular issues, and growth retardation.
- Oropharyngeal effects are also noted. These adverse events are often dependent on the ICS dose, duration of use, specific drug, administration method, and potential drug interactions.
- Strategies to minimize side effects involve titrating ICS to the lowest effective dose, periodic reassessment of treatment necessity, and awareness of drug interactions.
Impact:
- Highlights the importance of monitoring for and managing potential adverse effects associated with ICS therapy.
- Emphasizes individualized treatment approaches, including dose adjustment and potential switching of ICS agents, to optimize patient safety and therapeutic outcomes in asthma care.
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