Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and Cox...
Nursing Evaluation01:15

Nursing Evaluation

The evaluation stage signals the end of the nursing process. The nurse gathers evaluative data to assess whether or not the patient has attained the expected results. Whereas the nurse collects data in the nursing assessment to identify the patient's health concerns, the evaluation stage data determines if the indicated health issues are resolved. Evaluative data collection includes two sections: the data acquired to evaluate patient outcomes and the time criteria for data collection.
Section...
Planning Nursing Care I01:21

Planning Nursing Care I

The planning phase of the nursing process helps nurses set priorities, outline patient-centered goals and expected outcomes, and tailor nursing interventions to align with the aligned care plan. Through the planning phase, the nurse applies critical thinking skills to align and develop interventions according to the patient's needs. It provides continuity of care allowing patients to receive the maximum benefit from treatment. It serves as a pilot plan for allocating individual staff to a...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Planning Nursing Care II01:29

Planning Nursing Care II

A nursing care plan can present in two forms: informal and formal. Informal is a care plan for the individual use of the nurse and goals they wish to accomplish during their shift. Informal care plans are not included in the patient chart. A formal nursing care plan is a written or computerized guide that organizes patient care. It is further subdivided into two: standardized and individualized care plans. Standardized care plans are pre-populated care plans for specific patient populations,...
Hazard Ratio01:12

Hazard Ratio

The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial evaluating a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Restriction-Weighted Q-Space Trajectory Imaging (ResQ): Toward Mapping Diffusion-Time Effects With Tensor-Valued Diffusion Encoding in Human Prostate Cancer Xenografts.

NMR in biomedicine·2026
Same author

D-chiro-inositol modulates brain insulin-related signaling and reduces amyloid burden, neuroinflammation and cognitive decline in preclinical models of Alzheimer's disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Radiotherapy with or without concurrent cetuximab in HPV-positive oropharyngeal squamous cell carcinoma - A pooled analysis from two ARTSCAN trials.

Clinical and translational radiation oncology·2026
Same author

Daily adaptive radiotherapy in head and neck squamous cell carcinoma can negatively impact organ at risk dosimetry.

Clinical and translational radiation oncology·2026
Same author

Proton pencil beam scanning lattice radiotherapy: Technical implementation and comparison against photon-based delivery.

The British journal of radiology·2026
Same author

Radiation Dose-Dependent Skin Toxicity and Therapeutic Advantage of FLASH Radiation Therapy Via Immune Modulation.

International journal of radiation oncology, biology, physics·2026
Same journal

Cardiotoxicity, survival, and dexrazoxane use in patients with soft tissue sarcoma: a Danish population‑based cohort study.

Acta oncologica (Stockholm, Sweden)·2026
Same journal

Overall survival following palliative immune checkpoint inhibitor treatment according to ECOG performance status: a large registry-based study.

Acta oncologica (Stockholm, Sweden)·2026
Same journal

Pathological characteristics and prognosis of very young patients with early breast cancer: a comparative analysis with older patients.

Acta oncologica (Stockholm, Sweden)·2026
Same journal

Recent survival trends in the most fatal cancers in the Nordic countries: gains in some but not in all.

Acta oncologica (Stockholm, Sweden)·2026
Same journal

First-in-human quantitative [¹⁵O]H₂O PET imaging of tumour blood flow at rest and during exercise in lymphoma patients.

Acta oncologica (Stockholm, Sweden)·2026
Same journal

Starshot field configuration in the linac isocentre size determination: a comparison of film and electronic portal imaging device measurements.

Acta oncologica (Stockholm, Sweden)·2026
See all related articles

Related Experiment Video

Updated: May 16, 2026

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources
05:18

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Treatment plan comparison using grading analysis based on clinical judgment.

Kristoffer Petersson1, Jacob Engellau, Per Nilsson

  • 1Department of Medical Radiation Physics, Clinical Sciences, Lund University, Lund, Sweden. Kristoffer.petersson@med.lu.se

Acta Oncologica (Stockholm, Sweden)
|December 18, 2012
PubMed
Summary
This summary is machine-generated.

Clinical grading analysis (CGA) effectively compares radiation therapy plans, correlating well with dosimetric data. This method helps identify patient benefits from advanced techniques like helical tomotherapy (HTT) and intensity-modulated radiation therapy (IMRT).

Related Experiment Videos

Last Updated: May 16, 2026

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources
05:18

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Area of Science:

  • Radiation Oncology
  • Medical Physics

Background:

  • Traditional treatment plan comparisons rely on dosimetric evaluation.
  • Radiation oncologists' (ROs) clinical expertise is crucial for assessing treatment efficacy.
  • Advanced radiotherapy techniques require robust methods for evaluation and comparison.

Purpose of the Study:

  • To evaluate the utility of Clinical Grading Analysis (CGA) for comparing radiation therapy treatment plans.
  • To assess the correlation between CGA results and established dosimetric parameters.
  • To determine the clinical relevance of CGA in distinguishing between different radiotherapy techniques.

Main Methods:

  • Ten experienced ROs assessed 23 patient cases comparing helical tomotherapy (HTT) and seven-beam step-and-shoot intensity-modulated radiation therapy (SS-IMRT) plans.
  • CGA was performed by grading plans based on perceived comparative performance.
  • CGA grades were analyzed against dose-volume statistics and equivalent uniform dose (EUD) data.

Main Results:

  • CGA identified significant plan differences in 8 out of 23 cases, favoring HTT in five and SS-IMRT in three.
  • CGA results showed good correlation with dose-volume statistics for target coverage and organ-at-risk doses.
  • Correlation with EUD was strong for clinical target volume (CTV) coverage but less clear for planning target volume (PTV) coverage.

Conclusions:

  • CGA is a valuable method for comparing radiotherapy treatment plans, offering a formalized approach for evaluating new techniques.
  • The method aids in identifying patients who benefit from specific advanced techniques (HTT, SS-IMRT).
  • CGA facilitates more optimal utilization of advanced treatment resources in clinical settings.