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Catecholamines and diagnoses in children.

G A Rogeness1, M A Javors, J W Maas

  • 1Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284-7792.

Journal of the American Academy of Child and Adolescent Psychiatry
|March 1, 1990
PubMed
Summary
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Noradrenergic function may differ in conduct disorder (CDU) versus anxiety/depressive disorders. Lower noradrenergic function was linked to CDU, while higher function was associated with anxiety/depressive disorders in this study.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Biochemistry

Background:

  • Noradrenergic (NA) system function is hypothesized to differ between undersocialized conduct disorder (CDU) and anxiety/depressive disorders.
  • Lower NA function may be characteristic of CDU, whereas higher NA function might be associated with anxiety/depressive disorders.

Purpose of the Study:

  • To investigate the relationship between noradrenergic function and diagnoses of conduct disorder (CDU) and anxiety/depressive disorders.
  • To compare catecholamine measures in individuals with low versus high plasma dopamine-beta-hydroxylase (D beta H) activity.

Main Methods:

  • Diagnostic assessments were conducted.
  • 24-hour urine catecholamine levels were measured.
  • Plasma dopamine-beta-hydroxylase (D beta H) activity was used to categorize subjects into low (<6 mumoles/min/L) and high (>15 mumoles/min/L) activity groups.

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Main Results:

  • Individuals in the low D beta H group exhibited lower levels of norepinephrine metabolism markers.
  • The low D beta H group received more diagnoses of CDU and fewer diagnoses of anxiety and depressive disorders.
  • Within each D beta H group, clinical and biological measures supported the hypothesized link between NA function and disorder diagnoses.

Conclusions:

  • Findings support the hypothesis that noradrenergic function is lower in undersocialized conduct disorder (CDU) and higher in anxiety/depressive disorders.
  • Plasma dopamine-beta-hydroxylase (D beta H) activity may serve as a biological marker differentiating these conditions.