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Formulation development and evaluation of lamivudine controlled release tablets using cross-linked sago starch
Akhilesh Vikram Singh1, Lila Kanta Nath
1Indian Institute of Science, Department of Materials Engineering, Biomaterials Lab, Bangalore, Karnataka, 560012, India. akhileshvikram@gmail.com
Expert Opinion on Drug Delivery
|December 18, 2012
Summary
This study developed controlled-release lamivudine tablets using cross-linked sago starch, demonstrating effective drug release kinetics and improved pharmacokinetic profiles compared to conventional formulations.
Area of Science:
- Pharmaceutical Sciences
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Modified starches, particularly cross-linked variants, are valuable in pharmaceutical formulations.
- Cross-linked starches have shown significant potential in advanced drug delivery applications.
Purpose of the Study:
- To develop controlled-release lamivudine tablets utilizing cross-linked sago starch.
- To evaluate the efficacy of cross-linked sago starch as a matrix for sustained drug release.
Main Methods:
- Cross-linked sago starch was synthesized using phosphorous oxychloride.
- Tablets were formulated and evaluated for physical characteristics, in vitro drug release, and in vivo pharmacokinetics in rabbits.
Main Results:
- The optimized formulation followed zero-order kinetics, with drug release governed by diffusion and erosion.
- Significant improvements in pharmacokinetic parameters (Tmax, Cmax, AUC, Vd, T1/2, MDT) were observed compared to the marketed Lamivir® tablet.
Conclusions:
- Cross-linked sago starch effectively controls drug release, offering a promising matrix for controlled and sustained drug formulations.
- This hydrophilic matrix system has broad applicability for various active pharmaceutical ingredients requiring modified release profiles.
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