Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleepwalking and Sleep Talking01:17

Sleepwalking and Sleep Talking

Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
Insomnia01:27

Insomnia

Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell-type targeted CRISPR/Cas9 Clock knockdown in mouse VTA dopamine neurons alter sleep, behavior, and cellular excitability.

bioRxiv : the preprint server for biology·2026
Same author

Selective and differential roles of PVH<sup>CRH</sup> neurotransmitters in diet-induced obesity in mice.

Nature communications·2026
Same author

Hypothalamic control of arousal.

Reviews in endocrine & metabolic disorders·2026
Same author

Insomnia Subtypes in Clinical Population According to the Insomnia Type Questionnaire (ITQ): A Multi-Centre Study in Spanish Sleep Clinics.

Journal of sleep research·2025
Same author

Aging and injury drive neuronal senescence in the dorsal root ganglia.

Nature neuroscience·2025
Same author

The Disputable Costs of Sleeping.

Biology·2025
Same journal

Pharmacological interventions for smoking cessation in patients with bipolar disorder.

Adicciones·2026
Same journal

Spanish Validation of the Smoking-Related Weight and Eating Episodes Test (SWEET).

Adicciones·2026
Same journal

Personality factors associated with alcohol, tobacco and marijuana use in adolescents: A longitudinal study.

Adicciones·2026
Same journal

A multidimensional measure of social networking addiction: Psychometric properties of AdiTec-I scores in Spanish-speaking adolescents and young adults.

Adicciones·2026
Same journal

Equity in healthcare: Why addiction consultation-liaison services should be present in all hospitals.

Adicciones·2026
Same journal

Jorge Manzanares: posthumous tribute to a great researcher, teacher, and friend.

Adicciones·2026
See all related articles

Related Experiment Video

Updated: May 16, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

[Relationships between sleep and addiction].

Francesca Cañellas, Luis de Lecea

    Adicciones
    |December 18, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Sleep disorders and substance abuse are complexly linked, with sleep problems worsening addiction and vice versa. The hypocretin/orexin system may be key to understanding and treating addiction relapse.

    More Related Videos

    Establishing a Device for Sleep Deprivation in Mice
    05:05

    Establishing a Device for Sleep Deprivation in Mice

    Published on: September 22, 2023

    Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
    03:46

    Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

    Published on: October 11, 2018

    Related Experiment Videos

    Last Updated: May 16, 2026

    A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
    06:23

    A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

    Published on: September 22, 2020

    Establishing a Device for Sleep Deprivation in Mice
    05:05

    Establishing a Device for Sleep Deprivation in Mice

    Published on: September 22, 2023

    Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
    03:46

    Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

    Published on: October 11, 2018

    Area of Science:

    • Neuroscience
    • Addiction Research
    • Sleep Medicine

    Background:

    • Substance use disorders (SUDs) and sleep disorders exhibit a bidirectional relationship, complicating treatment and recovery.
    • Sleep disturbances, including fragmented sleep, occur during both substance use and withdrawal phases.
    • The hypocretinergic system, crucial for sleep-wake cycle regulation, is increasingly implicated in addictive behaviors.

    Discussion:

    • Hypocretin/orexin (Hcrt/ox) neurons in the lateral hypothalamus interact with stress and reward pathways relevant to addiction.
    • Activation of the Hcrt/ox system can promote wakefulness and trigger relapse into compulsive drug-seeking behavior.
    • Hcrt/ox system activation may underlie the hyperarousal states observed in stress and addiction.

    Key Insights:

    • The Hcrt/ox system's role in linking sleep regulation with addiction mechanisms is a critical area of research.
    • Targeting the Hcrt/ox system offers potential for novel therapeutic strategies against addiction.
    • Understanding Hcrt/ox involvement is vital for preventing relapse in individuals with co-occurring SUDs and sleep disorders.

    Outlook:

    • Further research into Hcrt/ox system modulation could lead to innovative treatments for addiction.
    • Integrating sleep disorder management into addiction treatment protocols is essential for improving outcomes.
    • Elucidating the neurobiological links between sleep, stress, and reward is key to advancing addiction science.