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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: May 16, 2026

Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS)
14:15

Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS)

Published on: June 18, 2012

Tumor microenvironment and myeloid-derived suppressor cells.

Viktor Umansky1, Alexandra Sevko

  • 1Skin Cancer Unit, German Cancer Research Center, 69120, Heidelberg, Germany, v.umansky@dkfz.de.

Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society
|December 18, 2012
PubMed
Summary

Chronic inflammation fuels tumor progression. Myeloid-derived suppressor cells (MDSCs) are key players, suppressing anti-tumor immunity and promoting cancer growth and metastasis.

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Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS)
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Published on: November 28, 2019

Area of Science:

  • Immunology
  • Oncology
  • Cancer Biology

Background:

  • Tumor progression is linked to chronic inflammation in the tumor microenvironment.
  • Inflammatory factors and leukocyte infiltration characterize this environment.
  • Myeloid-derived suppressor cells (MDSCs) are crucial immune suppressors in tumors.

Purpose of the Study:

  • To review the interactions between MDSCs and tumor cells.
  • To elucidate how these interactions drive MDSC generation, activation, and migration.
  • To highlight the role of MDSCs in enhancing tumor progression.

Main Methods:

  • Literature review of existing research on MDSCs and tumor biology.
  • Analysis of the mechanisms underlying MDSC-tumor cell interplay.
  • Synthesis of information on MDSC functions in tumorigenesis, growth, and metastasis.

Main Results:

  • MDSCs inhibit T cell-mediated anti-tumor immunity.
  • MDSCs directly stimulate tumorigenesis, growth, and metastasis.
  • MDSCs enhance neoangiogenesis and facilitate metastatic formation.

Conclusions:

  • Understanding the MDSC-tumor cell interplay is vital for cancer research.
  • This knowledge is critical for developing novel tumor immunotherapy strategies.
  • Targeting MDSCs offers a promising avenue for cancer treatment.