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Digital clubbing

Malay Sarkar1, D M Mahesh, Irappa Madabhavi

  • 1Department of Pulmonary Medicine, Indira Gandhi Medical College, Shimla, India.

Lung India : Official Organ of Indian Chest Society
|December 18, 2012
PubMed

Insights

Digital clubbing, a key clinical sign, often indicates serious underlying diseases. Research suggests growth factors like PDGF and VEGF may cause clubbed fingers, highlighting its diagnostic importance.

Area of Science:

  • Medicine
  • Clinical Medicine
  • Pathophysiology

Background:

  • Digital clubbing is a significant clinical sign with ancient recognition in medicine.
  • Clubbed fingers are typically asymptomatic but can signal serious underlying conditions.
  • The precise pathogenesis of digital clubbing remains unclear.

Purpose of the Study:

  • To review the association between digital clubbing and various disease processes.
  • To discuss the clinical implications of digital clubbing.
  • To explore potential pathogenetic mechanisms involving growth factors.

Main Methods:

  • Literature review of studies on digital clubbing.
  • Analysis of clinical associations and implications.
  • Discussion of proposed pathogenetic factors.

Main Results:

  • Digital clubbing is linked to numerous diseases, underscoring its role as an indicator.
  • Platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) are implicated in clubbing development.
  • The review synthesizes current understanding of clubbing's etiology and significance.

Conclusions:

  • Digital clubbing is a critical clinical sign requiring thorough investigation.
  • Understanding the role of growth factors may offer new diagnostic or therapeutic insights.
  • Further research into the pathogenesis of digital clubbing is warranted.

Keywords:
Cancerdigital clubbinghypertrophic osteoarthropathymegakaryocytesvascular endothelial growth factor

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