Related Experiment Video
Updated: May 16, 2026

10:04
Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs
1Department of Sugery; University of Pittsburgh; Pittsburgh, PA USA.
Oncoimmunology
|December 18, 2012
Abstract:
Activated lymphocytes secrete dendritic cell (DC)-activating cytokines including tumor necrosis factor α and interferon γ, and induce Type-1-polarized DCs (DC1s). Lymphocyte-polarized DC1s secrete high levels of biologically active interleukin-12 (IL-12p70) and CXCL10 and show enhanced CTL-inducing activity. Our data demonstrate the feasibility of using autologous lymphocytes to enhance the immunogenic properties of DCs in a low-cost clinically-compatible process.
