[Improved methodology for quantitative determination of thiabendazole]
Noriko Furusho1, Noriko Otsuki, Takashi Ohtsuki
1Division of Food Additives, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Summary
This study improved thiabendazole analysis by removing toxic reagents. A new non-aqueous titration method accurately quantifies thiabendazole purity, enhancing food safety standards.
Area of Science:
- Analytical Chemistry
- Food Chemistry
Context:
- The quantitative analysis of thiabendazole in food additives relies on established methods.
- Current methods often involve toxic reagents like mercuric acetate and chromium trioxide.
- There is a need for safer and more environmentally friendly analytical techniques.
Purpose:
- To develop an improved, safer method for the quantitative determination of thiabendazole.
- To eliminate the use of hazardous reagents in thiabendazole analysis.
- To validate alternative non-aqueous titration solvent systems.
Summary:
- A novel non-aqueous titration method was developed for thiabendazole analysis, replacing toxic mercuric acetate and chromium trioxide.
- Acetic acid:acetic anhydride solvent systems (1:5 and 3:7 ratios) were found effective for purity determination via visual indicator or potentiometry.
- The improved method achieved high accuracy, with purity values of 99.9% (RSD=0.07%) and 99.7% (RSD=0.13%) respectively.
Impact:
- Provides a safer, greener alternative for thiabendazole quantification in food additive analysis.
- Enhances compliance with environmental and safety regulations in analytical laboratories.
- Contributes to more reliable and accurate food safety testing by improving analytical methodologies.
