Related Experiment Video

Updated: May 16, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors

Chris Carlsten1, Helen Dimich-Ward, Alexander Ferguson

  • 1Chan-Yeung Centre for Occupational and Environmental Lung Disease Unit, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. carlsten@mail.ubc.ca

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|December 19, 2012
PubMed

Insights

Early-onset persistent atopic dermatitis (AD) in high-risk infants predicts later allergic diseases, highlighting its role in the atopic march. The intervention did not prevent AD but impacted asthma outcomes.

Area of Science:

  • Pediatric Allergy and Immunology
  • Dermatology
  • Epidemiology

Background:

  • Atopic dermatitis (AD) is frequently linked with asthma and other allergic conditions in children.
  • Understanding the natural history of AD is crucial for managing allergic disease progression.

Purpose of the Study:

  • To investigate the long-term course of atopic dermatitis (AD) and its association with other allergic outcomes up to age 7 in a high-risk infant cohort.
  • To evaluate the impact of a primary asthma prevention intervention on AD development.

Main Methods:

  • A cohort of 373 high-risk infants, initially part of an asthma prevention trial, were monitored for asthma, AD, and allergic sensitization at ages 1, 2, and 7.
  • Data collection included clinical assessments and allergy testing.

Main Results:

  • The intervention effectively reduced asthma prevalence but did not impact AD rates.
  • Early-onset AD (by age 2) was linked to increased food allergen sensitization and later asthma diagnosis.
  • Persistent AD (continuing to age 7) was significantly associated with other atopic diseases and sensitization to both food and aeroallergens.

Conclusions:

  • Early-onset persistent atopic dermatitis (AD) in high-risk infants is a significant predictor of subsequent atopic diseases, confirming its role in the "atopic march."
  • Late-onset AD showed limited associations with allergic outcomes, except for Alternaria alternans sensitization.
Abstract

More Related Videos

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include: